Banthit Chetsawang

Banthit Chetsawang, Ph.D.,
Prof.
  Head of Research Center for Neuroscience

Ph.D. (Neuroscience, Mahidol U., Thailand.)
Ext. 1206
Email: banthit.che@mahidol.ac.th,  Sanook.san@mahidol.ac.th
Field of Research:Neurosciences

The main area of my research interests is focusing on neurodegeneration, neuroprotection and neurorestoration especially the death and survival signaling cascades in neuronal cell and the protective roles of melatonin on the neurodegeneration.

Selected Publications

1. Parameyong, A., Charngkaew, K., Govitrapong, P., and Chetsawang B*. Melatonin attenuates methamphetamine-induced disturbances in mitochondrial dynamics and degeneration in neuroblastoma SH-SY5Y cells. J Pineal Res. 2013. 55(3):313-323.

2. Suwanjang, W., Abramov, A.Y., Govitrapong, P., and Chetsawang, B*. Melatonin attenuates dexamethasone toxicity-induced oxidative stress, calpain and caspase activation in human neuroblastoma SH-SY5Y cells. J Steroid BiochemMol Biol. 2013. 138C:116-122.

3. Pirompul, N., Govitrapong, P., and Chetsawang, B*. Farnesyltransferase inhibitor attenuates methamphetamine toxicity-induced Ras proteins activation and cell death in neuroblastoma SH-SY5Y cells. NeurosciLett. 2013. 545:138-143.

4. Suwanjang, W., Holmström, K.M., Chetsawang, B., and Abramov, A.Y. Glucocorticoids reduce intracellular calcium concentration and protects neurons against glutamate toxicity. Cell Calcium. 2013. 53:256-263.

5. Chatchaisak, D., Srikiatkhachorn, A., Maneesri, le-Grand S., Govitrapong. P., and Chetsawang, B*. The role of calcitonin gene-related peptide on the increase in transient receptor potential vanilloid-1 levels in trigeminal ganglion and trigeminal nucleus caudalis activation of rat. J ChemNeuroanat. 2013. 47:50-56.

Full Publications

1. Sarlak, G., Jenwitheesuk, A., Chetsawang, B., and Govitrapong, P. Effects of melatonin on nervous system aging: neurogenesis and neurodegeneration. J Pharmacol Sci. 2013. 123(1):9-24.
2. Parameyong, A., Charngkaew, K., Govitrapong, P., and Chetsawang B*. Melatonin attenuates methamphetamine-induced disturbances in mitochondrial dynamics and degeneration in neuroblastoma SH-SY5Y cells. J Pineal Res. 2013. 55(3):313-323. 
3. Suwanjang, W., Abramov, A.Y., Govitrapong, P., and Chetsawang, B*. Melatonin attenuates dexamethasone toxicity-induced oxidative stress, calpain and caspase activation in human neuroblastoma SH-SY5Y cells. J Steroid BiochemMol Biol. 2013. 138C:116-122.
4. Pirompul, N., Govitrapong, P., and Chetsawang, B*. Farnesyltransferase inhibitor attenuates methamphetamine toxicity-induced Ras proteins activation and cell death in neuroblastoma SH-SY5Y cells. NeurosciLett. 2013. 545:138-143.
5. Suwanjang, W., Holmström, K.M., Chetsawang, B., and Abramov, A.Y. Glucocorticoids reduce intracellular calcium concentration and protects neurons against glutamate toxicity. Cell Calcium. 2013. 53:256-263. 
6. Chatchaisak, D., Srikiatkhachorn, A., Maneesri, le-Grand S., Govitrapong. P., and Chetsawang, B*. The role of calcitonin gene-related peptide on the increase in transient receptor potential vanilloid-1 levels in trigeminal ganglion and trigeminal nucleus caudalis activation of rat. J ChemNeuroanat. 2013. 47:50-56. 
7. Suwanjang, W., Phansuwan-Pujito, P., Govitrapong, P., and Chetsawang, B*. Calpastatin reduces calpain and caspase activation in methamphetamine-induced toxicity in human neuroblastoma SH-SY5Y cultured cells. NeurosciLett. 2012. 526:49-53.
8. Chetsawang, J., Suwanjang, W., Pirompul, N., Govitrapong, P., and Chetsawang, B*. Calpastatin reduces methamphetamine-induced induction in c-Jun phosphorylation, Bax and cell death in neuroblastoma SH-SY5Y cells. NeurosciLett. 2012. 506:7-11.
9. Chetsawang, J., Govitrapong, P., and Chetsawang, B*. Hydrogen peroxide toxicity induces Ras signaling in human neuroblastoma SH-SY5Y cultured cells. J Biomed Biotechnol. 2010. 2010.pii:803815.
10. Suwanjang, W., Phansuwan-Pujito, P., Govitrapong, P., andChetsawang, B*. The protective effect of melatonin on methamphetamine-induced calpain-dependent death pathway in human neuroblastoma SH-SY5Y cultured cells. J Pineal Res. 2010. 48:94-101.
11. Wisessmith, W., Phansuwan-Pujito, P., Govitrapong, P., andChetsawang, B*. Melatonin reduces induction of Bax, caspase and cell death in methamphetamine-treated human neuroblastoma SH-SY5Y cells. J Pineal Res.2009. 46:433-440.
12. Chetsawang, B*, Chetsawang, J., and Govitrapong, P. Protection against cell death and sustained tyrosine hydroxylase phosphorylation in hydrogen peroxide- and MPP+-treated human neuroblastoma cells with melatonin. J. Pineal Res. 200. 46: 36-42.
13. Chetsawang, B*.,Kooncumchoo, P., Govitrapong, P., and Ebadi, M. 1-methyl-4-phenyl-pyridinium ion-induced oxidative stress, c-Jun phosphorylation and DNA fragmentation factor-45 cleavage in SK-N-SH cells are averted by selegiline. Neurochem Int. 2008. 53: 283-288.
14. Chetsawang, J., Govitrapong, P., and Chetsawang, B*. Melatonin inhibits MPP+-induced caspase-mediated death pathway and DNA fragmentation factor-45 cleavage in SK-N-SH cultured cells. J. Pineal Res. 2007. 43: 115-120.
15. Chucharoen,P., Chetsawang, B*., Putthaprasart, C., Srikiatkhachorn, A., and Govitrapong, P. The presence of melatonin receptors and inhibitory effect of melatonin on hydrogen peroxide-induced endothelial nitric oxide synthase expression in bovine cerebral blood vessels. J. Pineal Res. 2007. 43: 35-41. 
16. Chetsawang, B*.,Putthaprasart, C., Phansuwan-Pujito, P., and Govitrapong, P. Melatonin protects against hydrogen peroxide-induced cell death signaling in SH-SY5Y cultured cells: involvement of nuclear factor kappa B, Bax and Bcl-2. J. Pineal Res. 2006; 41:116-123.
17. Phansuwan-Pujito, P., Boontem, P., Chetsawng, B., Ebadi, M. and Govitrapong, P. Dopamine transporter immunoreactive terminals in the bovine pineal gland. Neurosci. Lett. 2006. 403:78-83. 
18. Chetsawang, B., and Govitrapong, P. Stimulatory effect of morphine on rat pineal melatonin synthesis via a cyclic AMP-dependent transcription pathway. Neurosci. Lett. 2005. 389: 57-60.
19. Mukda, S., Chetsawang, B., Govitrapong, P., Schmidt, P.T., Hay-Schmidt, A., and Moller, M. Tachykinin and tachykinin-receptors in the rat pineal gland. Eur. J. Neurosci. 2005. 21: 2743-2751.
20. Chesawang, B., Govitrapong, P., and Ebadi, M. The neuroprotective effect of melatonin against the induction of c-Jun phosphorylation by 6-hydroxydopamine on SK-N-SH cells. Neurosci. Lett. 2004. 371: 205-208.
21. Santanavanich, C., Chetsawang, B., Ebadi, M., and Govitrapong, P. Effects of D1- and D2-dopamine receptor activation on melatonin synthesis in bovine pinealocytes. J. Pineal Res. 2003. 35 (3):169-176.
22. Jongkamonwiwat, N., Phansuwan-Pujito, P., Sarapoke, P., Chetsawang, B., Casalotti, S.O., Forge, A., Dodson, H., and Govitrapong, P. The presence of opioid receptors in rat inner ear.Hear Res. 2003. 181(1-2):85-93.
23. Chucharoen, P., Chetsawang, B.., Srikiatkhachorn, A., and Govitrapong, P. Melatonin receptor expression in rat cerebral artery. Neurosci. Lett. 2003. 341(3):259-261.
24. Ebadi, M., Sharma, S., Muralikrishnan, D., Shavali, S., Eken, J., Sangchot, P., Chetsawang, B., and Brekke, L. Metallothionein provides ubiquinone-mediated neuroprotection in Parkinson’s disease. Proc. West. Pharmacol. Soc. 2002. 45:36-38.
25. Govitrapong, P., Sawlom, S., Chetsawang, B., Sangchot, P., and Ebadi, M. The bovine pineal gland contains delta and mu but not kappa or ORL1 opioid receptor subtypes. Proc. West. Pharmacol. Soc. 2002. 45:32-35.
26. Sangchot, P., Sharma, S., Chetsawang, B., Porter, J., Govitrapong, P., and Ebadi, M. Deferoxamine attenuates iron-induced oxidative stress and prevents mitochondrial aggregation and alpha-synuclein translocation in SK-N-SH cells in culture. Dev. Neurosci. 2002. 24(2-3):143-153. 
27. Chetsawang, B., Govitrapong, P., and Møller, M. The effects of adrenergic agonists on c-fos, jun-B and nitric oxide synthase-like immunoreactivities in cultured rat pinealocytes. J. Pineal Res. 2001. 31: 186-192.
28. Chetsawang, B., Casalotti, S.O., Phansuwan-Pujito, P., Kotchabhakdi, N., and Govitrapong, P. Gene expressions of opioid receptors and G-proteins in pineal glands. Biochem. Biophys. Res. Commun. 1999. 262(3): 775-780.
29. Govitrapong, P., Jitjaijamjang, W., Chetsawang, B., Phansuwan-Pujito, P., and Ebadi, M. Existence and function of opioid receptors on mammalian pinealocytes. J. Pineal Res. 1998. 24: 201-208.
30. Chetsawang, B*.,Riol, H., Levesque, G., and Murthy, M,R.V. Transcription of “slow virus” dementia prion protein gene in lymphocytes of human blood. J. Sci. Soc. Thailand. 1993. 19: 97-102.
31. Chetsawang, B*.,Kotchabhakdi, N., Cherdchu, C., and Govitrapong, P. Collagenase diminished muscarinic receptor binding in partially purified bovine adrenal chromaffin cells. J. Sci. Soc. Thailand. 1990. 16(3/4): 177-185.

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