Kittiphong Paiboonsukwong

Kittiphong Paiboonsukwong, M.D., Ph.D.

  Assistant Director for Innovation Development

Ph.D. (Molecular Genetics and Genetic Engineering), Mahidol University, 2004
Ext. 1314
Email:    kittiphong.pai@mahidol.ac.th
Field of Research: Prevention and control of thalassemia in Southeast Asia

   Thalassemia and abnormal hemoglobin are the most common monogenic disorders and it has been estimated that approximately 5.2% of the world population are carriers. It has been estimated that the conception of homozygous beta-thalassemia and beta-thalassemia/Hb E in Southeast Asia is 0.24 and 0.25 per 1000 birth, respectively. Many thousands of these beta-thalassemia disorders are living in Southeast Asia. The alpha-thalassemia is widespread throughout Southeast Asia in which 5-15% of the population had some form of alpha-thalassemias. Because of high prevalence of both alpha thalassemia-1 and alpha- thalassemia-2 in these populations, HbH disease and Hb Bart’s hydrops fetalis are seen frequently. This causes public health burden for the region. Increasing number of labor migration among Southeast Asian countries pose a major problem in prevention, control and prenatal diagnosis for thalassemia disease in this area due to a difficult characterization of uncommon or unique mutations. Up-to-date epidemiological data and nature of thalassemia mutations are still lacking in many countries in this region. Reliable data is needed to provide evidence of the public health burden in order to develop the national control programs.

     A multicenter was designed to collect epidemiological, clinical and therapeutic information on thalassemia patients in Southeast Asian countries. Thalassemia diagnosis will be performed by complete blood cell (CBC) measurement, hemoglobin typing and DNA analysis.

Selected Publications

1. Paiboonsukwong K, Choi I, Matsushima T, Abe Y, Nishimura J, Winichagoon P, Fucharoen S, Nawata H, *Muta K. The Signaling Pathways of Erythropoietin and Interferon γ in Preventing the Apoptosis of Mature Erythroid Progenitor Cells. Int J Hematol. 2003 Dec, 78(5): 421-428.
2. Paiboonsukwong K, Ohbayashi F, Shiiba H, Aizawa E, Yamashita T, *Mitani K. Correction of mutant Fanconi anemia gene by homologous recombination in human hematopoietic cells using adeno-associated virus vector. J Gene Med. 2009 Nov;11(11):1012-9.

Full Publications

1. Paiboonsukwong K, Choi I, Matsushima T, Abe Y, Nishimura J, Winichagoon P, Fucharoen S, Nawata H, *Muta K. The Signaling Pathways of Erythropoietin and Interferon γ in Preventing the Apoptosis of Mature Erythroid Progenitor Cells. Int J Hematol. 2003 Dec, 78(5): 421-428.
2. Paiboonsukwong K, Ohbayashi F, Shiiba H, Aizawa E, Yamashita T, *Mitani K. Correction of mutant Fanconi anemia gene by homologous recombination in human hematopoietic cells using adeno-associated virus vector. J Gene Med. 2009 Nov;11(11):1012-9.

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