Molecular Medical Biosciences Cluster

Bacterial Protein Toxin

Studies an interaction of mosquito larvicidal toxins and their receptors Aedes aegypti mosquito is an important vector of dengue fever causing global death. Cry4 and Cry11 toxins produced from the Bacillus thuringiensis bacteria are specifically toxic to mosquito larvae. I am interested in an action mechanism of Cry4Ba, toxin-receptor interaction with its applications through structure-function relationship, cytolytic pore-formation, cellular & molecular biology and immunological techniques.

Protein Production

Introduction: Less than 3% of the human genome encodesproteins, and more than half of the transcripts in human appear to be non-coding (nc) RNAs. This fact redefined the paradigm of genetic flow (The Central Dogma), and shed light on the hidden roles of ncRNAs in regulation of cellular processes. There are likely to be many more unknown ncRNAs that are fulfilling a wide range of unexpected functions in eukaryotic biology.

Virology

  • To conduct research on the molecular pathology of viral diseases of significance to Thailand.
  • To continue research on the dengue virus: host cell interaction and to initiate new projects on other viruses.

Stem Cell

Our major goal is to promote the development of innovative discoveries and translational strategies related to stem cells. We are interested in understanding the mechanisms of blood and neural development, modeling blood and neural disorders, and direct converting of adult fibroblast into other specific lineage.

Others

At our institute, there are many people interested in the application of multidisciplinary approaches and cutting edge technology to advance understanding of mechanism of allergy, computational drug design, nutrient-gene interaction, RNA biology, novel non-coding RNA, novel enzyme assembly, and single cell based method for antibiotic study.