Nuanchan Chutabhakdikul

Nuanchan Chutabhakdikul, Ph.D.,
Assoc. Prof.

Nuanchan2Ph.D. (Neuroscience), Mahidol University, Thailand, 1998
Ext. 1203
Email:   nuanchan.chu@mahidol.ac.thgrnjgnew@gmail.com

1.Fetal Programming effects of Glucocorticoids and adult brain diseases

Intra-uterine environment is now believed to play a major role in the origins of adult diseases. Prenatal stress has been linked to an emergence of adult mental health problems and increased risk of age-related memory and cognitive deficits. Our current research aims to understand the underlying mechanisms that link between early life stress and an emergence of adult diseases i.e., psychiatric disorders, age-related memory and cognitive deficits, etc. Our research activities focus on the effects of maternal stress on the development of NMDA and GABAA receptors, various scaffolding proteins and adhesion molecules that anchor the receptors in the pup’s brain. We also studied how prenatal stress alters neurogenesis and neural migration of both projection neurons and interneurons in the cerebral cortex. Our attempt is to reprogram the effect of maternal stress on learning and memory deficit in the offspring as adult by various prevention paradigms such as maternal exercises and enrich environment with hope to support proper development of the young brain.

2.Development of executive functions in normal and special child

Executive function (EF) refers to the ability to execute appropriate actions and to inhibit inappropriate actions for the attainment of a specific goal. EF is important for school readiness and academic achievement more than IQ. Our research activities focus on the development of tool for assessing executive functions in early childhood and finding intervention and educational approach which may enhance EF in child and adolescence. Our goal is to find the best way to support EF development and protect EF dysfunction both in normal and special child.

Selected Publications

1. Chutabhakdikul N*, Surakul P. Prenatal stress increased Snk Polo-like kinase 2, SCF beta-TrCP ubiquitin ligase and ubiquitination of SPAR in the hippocampus of the offspring at adulthood. International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience. 2013; 31(7):560-7.

2. Surakul P, Weerachatyanukul W, Chutabhakdikul N*. Repeated carbenoxolone injections during late pregnancy alter Snk-SPAR and PSD-95 expression in the hippocampus of rat pups. Neuroscience letters. 2011; 494(1):75-9.

3. Laohawattanakun J, Chearskul S, Dumrongphol H, Jutapakdeegul N, Yensukjai J, Khumphan N, et al. Influence of music training on academic examination-induced stress in Thai adolescents. Neuroscience letters. 2011; 487(3):310-2.

4.Afadlal S, Polaboon N, Surakul P, Govitrapong P, Jutapakdeegul N*. Prenatal stress alters presynaptic marker proteins in the hippocampus of rat pups. Neuroscience letters. 2010; 470(1):24-7.

5.Jutapakdeegul N*, Afadlal S, Polaboon N, Phansuwan-Pujito P, Govitrapong P. Repeated restraint stress and corticosterone injections during late pregnancy alter GAP-43 expression in the hippocampus and prefrontal cortex of rat pups. International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience. 2010; 28(1):83-90.

Full Publications

1. Chutabhakdikul N*, Surakul P. Prenatal stress increased Snk Polo-like kinase 2, SCF beta-TrCP ubiquitin ligase and ubiquitination of SPAR in the hippocampus of the offspring at adulthood. International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience. 2013; 31(7):560-7.

2. Surakul P, Weerachatyanukul W, Chutabhakdikul N*. Repeated carbenoxolone injections during late pregnancy alter Snk-SPAR and PSD-95 expression in the hippocampus of rat pups. Neuroscience letters. 2011; 494(1):75-9.

3. Laohawattanakun J, Chearskul S, Dumrongphol H, Jutapakdeegul N, Yensukjai J, Khumphan N, et al. Influence of music training on academic examination-induced stress in Thai adolescents. Neuroscience letters. 2011; 487(3):310-2.

4.Afadlal S, Polaboon N, Surakul P, Govitrapong P, Jutapakdeegul N*. Prenatal stress alters presynaptic marker proteins in the hippocampus of rat pups. Neuroscience letters. 2010; 470(1):24-7.

5.Jutapakdeegul N*, Afadlal S, Polaboon N, Phansuwan-Pujito P, Govitrapong P. Repeated restraint stress and corticosterone injections during late pregnancy alter GAP-43 expression in the hippocampus and prefrontal cortex of rat pups. International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience. 2010; 28(1):83-90.

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