Sukonthar Ngampramuan

Sukonthar Ngampramuan, Ph.D.,
Asst. Prof.

Sukonthar2Ph.D. (Neuroscience), Mahidol University, Thailand, 2008
Ext:1206
Email:  sukonthar.nga@mahidol.ac.th
Research Interests : Neuroscience

My current research in Neurocardiology investigates the principles of interaction between the brain and the heart. I am interested in the brain control of cardiac regulation in responses to psychological stresses ? a clinically important and poorly understood area. I have recently demonstrated that sudden altering stimuli can precipitate potentially fatal ventricular arrhythmias in animals, just as it sometimes happens in humans. In addition to conscious animal models, I use anesthetized animals to study descending pathways to the heart and their neurochemistry. I am currently running experimental protocols with telemetric recordings of cardiac parameters and stereotactic microinjection of pharmacological substances into the brain areas involved in the cardiac control.

In collaboration with Dr. Eugene Nailvaiko (Newcastle, AU), we have described the pharmacological inhibition of the amygdala prevents restraint?stress tachycardia in rats and discovered that the activation of serotonin 1A agonist (5?HT1A) receptor in the medullary raphe area also reduces tachycardia during restraint stress. This discovery has led me to hypothesize that 5?HT1A receptors may represent a mechanism link between stress and cardiac malfunction. I expect my future work would provide new understandings about stress?related cardiac diseases.

Selected Publications

1.Ngampramuan, S, Baumert M., Beig, M.I., Kotchabhakdi, N., and Nalivaiko, E. (2008). Activation of 5?HT(1A) receptors attenuates tachycardia induced by restraint stress in rats. Am J Physiol Regul Integr Comp Physiol 294, R132?141.

2.Salome, N., Ngampramuan, S., and Nalivaiko, E. (2007). Intra?amygdala injection of GABAA agonist, muscimol, reduces tachycardia and modifies cardiac sympatho?vagal balance during restraint stress in rats. Neuroscience 148, 335?341.

Full Publications

1.Ngampramuan, S, Baumert M., Beig, M.I., Kotchabhakdi, N., and Nalivaiko, E. (2008). Activation of 5?HT(1A) receptors attenuates tachycardia induced by restraint stress in rats. Am J Physiol Regul Integr Comp Physiol 294, R132?141.

2.Salome, N., Ngampramuan, S., and Nalivaiko, E. (2007). Intra?amygdala injection of GABAA agonist, muscimol, reduces tachycardia and modifies cardiac sympatho?vagal balance during restraint stress in rats. Neuroscience 148, 335?341.

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