(Mapping Analogous Nuclei Onto Residue And Affinity) for identifying protein-ligand fragment interaction, pathways and SNPs.
Thalassemia is a wide spread genetic disease presented as chronic anemia. Hemoglobin Bart’s hydrops fetalis, the most severe form of thalassemia, is fatal and uniformly results in still birth when there is a homozygous defect of alpha thalassemia 1.This can be avoided if parents who are carriers for the alpha thalassemia 1 know their genetic status. Thank to an invention of a strip test for rapid detection of hemoglobin Bart’s, screening for the alpha thalassemia 1 carrier can be simply done. A multicenter validation study of this immunochromatographic strip test has shown that the test is highly sensitive and specific, thus rule out mass populations for further alpha thalassemia 1 detection by PCR-based analysis.
We know Jason and the Argonauts who retrieved the Golden Fleece and fought hydra, cyclop and all those monsters. But, this is about another kind of Argonaute, which is a key protein in RNA silencing.